New therapeutic target for most common solid cancer in childhood?

A team of researchers, led by Patrick Mehlen, at Université de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC) as potential therapeutic targets for the treatment of neuroblastoma - the most frequent solid tumor in young children - by studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks.

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