Virtual screening leads to real progress in drug design

Around 150,000 people per year get African sleeping sickness, a disease spread by the biting tsetse fly and caused by the parasite Trypanosoma brucei. Unless treated, the illness is invariably fatal. And the only available medicines are either difficult to administer, expensive, or toxic. The widely used drug melarsoprol, for example, is essentially arsenic dissolved in antifreeze.

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