New sensors can detect single protein molecules
For the first time, MIT engineers have designed sensors that can detect single protein molecules as they are secreted by cells or even a single cell. These sensors, which consist of chemically modified carbon nanotubes, could help scientists with any application that requires detecting very small amounts of protein, such as tracking viral infection, monitoring cells’ manufacturing of useful proteins, or revealing food contamination, the researchers say. “We hope to use sensor arrays like this to look for the ‘needle in a haystack,’” says Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering at MIT. “These arrays represent the most sensitive molecular sensing platforms that we have available to us technologically. You can functionalize them so you can see the stochastic fluctuations of single molecules binding to them.” Strano is the senior author of a Jan. 23 Nature Nanotechnology paper describing the new sensors. The paper’s lead author is Markita Landry, a...