Drug patch treatment sees new breakthrough
An assistant professor with the Virginia Tech -- Wake Forest School of Biomedical Engineering has developed a flexible microneedle patch that allows drugs to be delivered directly and fully through the skin. The new patch can quicken drug delivery time while cutting waste, and can likely minimize side-effects in some cases, notable in vaccinations and cancer therapy. News of the delivery technology was published in a recent issue of the scientific journal, Advanced Materials.
Leading development of the flexible patch was Lissett Bickford, now an assistant professor and researcher of biomedical engineering and the mechanical engineering, both part of the Virginia Tech College of Engineering. Work on the technology was completed while Bickford was a post-doctoral research associate at the University of North Carolina Chapel Hill.
Microneedle patch technology used on the skin has existed for several years, each patch containing an array of hundreds of micron-sized needles that pierce the skin and dissolve, delivering embedded therapeutics. However, because of their rigid chemical makeup, the patches proved difficult in fully piercing into the skin, creating a waste of drug material and a slowed delivery time. Additionally, the patches also have been difficult to produce in bulk; typical fabrication procedures have required centrifugation.
Bickford, with her research team, including Chapel Hill graduate student Katherine A. Moga, were able to develop a new flexible microneedle patch that forms to the skin directly -- think a regular household bandage -- and then fully pierces the skin and dissolves. Bickford said the softer, more malleable and water-soluble material also allows for more precise control over the shape, size, and composition of the patch, with little to no waste.
The nanoparticle, micro-molding patch is based on Particle Replication In Non-wetting Templates (PRINT for short) technology, developed by University of North Carolina researcher and professor Joseph DeSimone. Unlike other methods for making these patches, the new technology allows for quicker and greater wide-scale production, reducing related costs.
Source: Virginia Tech
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Molybdenum disulfide holds promise for light absorption
- Finding Zika one paper disc at a time
- Zika virus may cause microcephaly by hijacking human immune molecule
- Rapid, low-cost, and portable test for Zika effectively detects virus in monkeys
- Evidence that Zika causes neural stem cells to self-destruct
- Perceived diversity in neighborhoods is related to more prejudice, study finds
- 'Adaptive protein crystal' could form new kind of protective material
- Inheritable bacterium controls Aedes mosquitoes' ability to transmit Zika
- First global analysis indicates leopards have lost nearly 75 percent of their historic range
- Bats' flight technique could lead to better drones
- Light echoes give clues to planet nursery around star
- Coral 'toolkit' allows floating larvae to transform into reef skeletons
- New tool puts a consistent value on experts' uncertainty on climate change models
- Scientists establish first map of the sea lion brain
- Beach buoys deployed to detect beach contamination