Mayo Clinic identifies promising treatment for inherited form of kidney disease
A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented November 3 at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine.
The multicenter study found tolvaptan demonstrated a nearly 50 percent reduction in the rate of increase in total kidney volume (a measurement of kidney cyst growth) in ADPKD patients over the study period, compared to placebo.
"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," says lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.
"In most patients with this disease, relentless cyst growth within the kidneys destroys the tissue, causes hypertension and painful complications, and negatively impacts the quality of life," Dr. Torres says. "The results of this study reveal a potential treatment that blunts kidney growth, lessens associated symptoms and slows kidney function decline when given over three years."
While the trial findings are encouraging, tolvaptan has not yet been approved for this indication, Dr. Torres notes.
The study was funded by Otsuka Pharmaceuticals.
Source: Mayo Clinic
- Promising treatment for inherited form of kidney diseasefrom Science DailySun, 4 Nov 2012, 20:04:41 EST
- Advancing understanding of treatment through clinical trialsfrom Science DailySun, 4 Nov 2012, 20:02:02 EST
- Mayo Clinic Identifies Promising Treatment for Inherited Form of Kidney Diseasefrom Newswise - ScinewsSat, 3 Nov 2012, 23:30:53 EDT
- Stereotactic radiosurgery shows promise for kidney cancerfrom Science DailyThu, 1 Nov 2012, 11:30:42 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- NIH study confirms benefits of intensive blood pressure management among seniors aged 75 and older
- Physicists create first metamaterial with rewritable magnetic ordering
- Temperature influences gene expression, life cycle in vibrio cholerae
- Developing tropical storm triggers deadly landslides in Sri Lanka
- Tropical Cyclone 01B named Roanu and is strengthening
- Attosecond physics: Using laser pulses to direct protons
- Badges acknowledging open practices significantly increase reported data
- Poaching of old forest elephant matriarchs threatens rainforests
- Ancient Irish musical history found in modern India
- NASA satellite data could help reduce flights sidelined by volcanic eruptions