Can't focus? Maybe it's the wrong time of month
Feeling a little sluggish and having trouble concentrating? Hormones might be to blame according to new research from Concordia University published in the journal Brain and Cognition. The study shows that high estrogen levels are associated with an inability to pay attention and learn – the first such paper to report how this impediment can be due to a direct effect of the hormone on mature brain structures. "Although estrogen is known to play a significant role in learning and memory, there has been no clear consensus on its effect," says senior author Wayne Brake, an associate professor at Concordia's Center for Studies in Behavioural Neurobiology. "Our findings, using a well-established model of learning called latent inhibition, shows conclusively that high estrogen levels inhibit the cognitive ability in female rodents."
Human females have high estrogen levels while they are ovulating. These high levels have also been shown to interfere with women's ability to pay attention.
"The similarity between human studies and our findings suggest that we have a good model for human learning," says first author Matthew Quinlan, a former Concordia doctoral student now a lecturer at California State University San Bernadino. "Rodent research is invaluable to us. We can tease out the real contributors and their respective roles in these systems. It is much more difficult to conduct comparable experiments in humans."
Latent inhibition: A model of learning
Latent inhibition is observed in many species and is believed to be the important part of learning, which enables individuals to interact successfully in their environment. It is a test of new memory formation.
In the Brake protocol, rats received a pre-exposure phase during which they were repeatedly exposed to a tone, with no consequence. Once they became used to this tone and ignored it, the test dynamics changed and another stimulus was linked to the tone. Rats with low levels of estrogen quickly learned that the tone was associated with the new stimulus whereas those with higher levels of estrogen took longer to form this memory.
"We only observed this effect in adult female rats," says Brake. "This and our other findings indicate that estrogen directly effects the brain, perhaps by interfering with brain signaling molecules. Our study helps clear up the controversy about the effects of estrogen, the next step is to look at how this occurs."
Source: Concordia University
- Can't focus? Maybe it's the wrong time of month, finds estrogen study on attention and learningfrom Science DailyFri, 24 Sep 2010, 11:21:14 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Nitrogen fingerprint in biomolecules could be from early sun
- Climate detectives reveal handprint of human caused climate change in Australia
- Alcohol makes smiles more 'contagious,' but only for men
- Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence
- Plants prepackage beneficial microbes in their seeds
- Preference for built-up habitats could explain rapid spread of the tree bumblebee in UK
- Clear skies on exo-Neptune
- Earth's water is older than the sun
- Tooth buried in bone shows prehistoric predators tangled across land, sea
- Talk therapy -- not medication -- best for social anxiety disorder, large study finds
- Ancient mammal relatives were active at night 100 million years before origin of mammals
- Rosetta-Alice spectrograph obtains first far ultraviolet spectra of a cometary surface
- Giant garbage patches help redefine ocean boundaries
- Newly identified galactic supercluster is home to the Milky Way
- How much gravity is enough?