Study assesses potential health complications for obese kidney donors
Individuals who are obese face certain risks when donating their kidneys, but their kidney function remains strong one year later, according to a paper being presented at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania. As the waiting list for kidney transplants grows, transplant centers are working to facilitate more live donor transplantations. However, there are many unanswered questions related to the potential long-term risks of kidney donation for donors with risk factors for future kidney disease — such as obesity.
To investigate the issue, Peter Reese, MD, and his colleagues at the University of Pennsylvania in Philadelphia, Pennsylvania, report on the use of kidneys donated by live obese and non-obese individuals at transplant centers across the United States. The study included 2004-2005 registry data from the Organ Procurement and Transplantation Network. In all, the investigators analyzed data from more than 5,300 donors, among whom nearly 1,200 (22.5%) were obese.
The study revealed that obesity is common among live donors, particularly among African- and Hispanic-American donors, who also are more likely to develop kidney disease. Additionally, the research indicates that compared with non-obese donors, obese donors have higher blood pressure prior to kidney donation.
To compare the health of obese and non-obese donors after surgery, the investigators measured blood pressure, hypertension status, and kidney function at six and twelve months after kidney donation. Obese donors had slightly higher blood pressure and were more likely to be hypertensive than non-obese donors. However, obese donors did not have worse kidney function than non-obese donors.
The study's major limitation was missing data on donor outcomes at follow-up. For instance, approximately 40% of donors had no data on kidney function reported at 6 months.
The authors stress that while this study indicates that obese individuals do not suffer from serious short-term adverse outcomes following kidney donation, the long-term risks to obese donors are uncertain. Uncovering these risks is important because many potential donors are strongly motivated to help loved ones but should also be aware of the risks to themselves. "Transplant centers must work hard to inform live donors about risks, but there are many unknowns," said Reese. He noted that studies on health outcomes at 10 or 20 years after donation would help clarify the risks to obese donors, but such long-term data are currently not available.
Source: American Society of Nephrology
Articles on the same topic
- Preventing anemia is important to kidney disease patients' quality of lifeTue, 11 Nov 2008, 15:08:36 EST
- Experts discuss effects of chronic kidney disease on women's sexual healthFri, 7 Nov 2008, 19:28:45 EST
- Due to atherosclerosis, stents are not beneficial for patients with narrow kidney arteriesFri, 7 Nov 2008, 18:21:37 EST
- People who develop kidney stones are at increased risk for chronic kidney diseaseFri, 7 Nov 2008, 17:57:03 EST
- Behavioral therapy helps overcome depression in kidney disease patients on dialysisFri, 7 Nov 2008, 17:57:00 EST
- Maternal and fetal outcomes in kidney donors are similar to non-donorsFri, 7 Nov 2008, 17:36:38 EST
- New equation provides more accurate estimates of kidney functionFri, 7 Nov 2008, 14:56:38 EST
- Impact of reform measures on nephrology practice and patient care explainedFri, 7 Nov 2008, 13:28:43 EST
- Experts discuss problems and solutions to inequities in kidney transplant allocationThu, 6 Nov 2008, 19:21:54 EST
- ERSD, heart disease and African-Americans with hypertensive nephrosclerosisThu, 6 Nov 2008, 18:56:28 EST
- Study compares survival following different heart disease treatments in patients with ESRDThu, 6 Nov 2008, 18:43:34 EST
- Kidney transplantation provides cognitive benefits for patients with kidney diseaseThu, 6 Nov 2008, 11:28:52 EST
- MYH9 gene variations help explain high rate of kidney disease in African-AmericansThu, 30 Oct 2008, 10:57:00 EDT
- African-American Canadians who receive kidney transplants fare better than those in USWed, 29 Oct 2008, 18:16:10 EDT
- Problems And Solutions To Inequities In Kidney Transplant Allocationfrom Science DailySat, 8 Nov 2008, 16:08:13 EST
- Kidney Transplantation Can Improve Mental Performance, Study Findsfrom Science DailySat, 8 Nov 2008, 16:07:43 EST
- New equation provides more accurate estimates of kidney functionfrom PhysorgFri, 7 Nov 2008, 14:56:12 EST
- ERSD, heart disease and African-Americans with hypertensive nephrosclerosisfrom PhysorgFri, 7 Nov 2008, 10:28:29 EST
- Problems And Solutions To Inequities In Kidney Transplant Allocationfrom Science DailyThu, 6 Nov 2008, 20:28:47 EST
- Kidney Transplantation Can Improve Mental Performance, Study Findsfrom Science DailyThu, 6 Nov 2008, 20:28:24 EST
- Study compares survival following different heart disease treatments in patients with ESRDfrom PhysorgThu, 6 Nov 2008, 18:42:26 EST
- Kidney transplantation provides cognitive benefits for patients with kidney diseasefrom PhysorgThu, 6 Nov 2008, 11:56:13 EST
- African-American Canadians Who Receive Kidney Transplants Fare Better Than Those In USfrom Science DailyMon, 3 Nov 2008, 16:07:48 EST
- African-American Canadians Who Receive Kidney Transplants Fare Better Than Those In USfrom Science DailySun, 2 Nov 2008, 23:35:44 EST
- African-American Canadians who receive kidney transplants fare better than those in USfrom PhysorgWed, 29 Oct 2008, 18:14:39 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- North American forests unlikely to save us from climate change, study finds
- Prostate cancer: should screening test procedures be tightened again?
- Computer scientists find way to make all that glitters more realistic in computer graphics
- Can palm oil be sustainable?
- Super-eruptions may give a year's warning before they blow