Mechanism of mutant histone protein in childhood brain cancer revealed
Friday, March 29, 2013 - 16:40
in Biology & Nature
Scientists in David Allis’s laboratory have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins. More »