How to make the gene-editing tool CRISPR work even better

Thursday, August 2, 2018 - 14:40 in Biology & Nature

Scientists have found conclusive evidence that Cas9, the most popular enzyme currently used in CRISPR gene editing, is less effective and precise than one of the lesser-used CRISPR proteins, Cas12a. Because Cas9 is more likely to edit the wrong part of a plant's or animal's genome, disrupting healthy functions, the scientists make the case that switching to Cas12a would lead to safer and more effective gene editing.

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