ALS protein dynamics highlight delicate balance between self-association and aggregation
Thursday, January 7, 2016 - 11:45
in Physics & Chemistry
The ALS-related protein TDP-43 takes the first steps toward pathologic aggregation as part of its normal function, according to a new study. The study supports the emerging idea that protein aggregation in neurologic disease may be an exaggeration of the normal functions of the aggregating proteins.