New study challenges link between HLA class I hyperexpression in pancreas, type 1 diabetes
Tuesday, January 6, 2015 - 18:41
in Health & Medicine
The cause of type 1 diabetes remains unknown. Several studies using immunohistochemistry (IHC) have independently reported hyperexpression of human leukocyte antigen (HLA) class I on pancreatic islet cells in young patients with recent-onset type 1 diabetes. Investigators have therefore suggested that HLA hyperexpression may be an important first step in the development of type 1 diabetes. However, a new study challenges these findings .