Novel drug action against solid tumors explained
Tuesday, August 12, 2014 - 13:30
in Biology & Nature
Researchers have discovered how a drug that deprives the cells of a key amino acid specifically kills cancer cells. The study describes how arginine starvation specifically kills tumor cells by a novel mechanism involving mitochondria dysfunction, reactive oxygen species generation, nuclear DNA leakage and chromatin autophagy, where leaked DNA is captured and "eaten" by giant autophagosomes.