Transmission of tangles in Alzheimer's mice provides more authentic model of tau pathology
Tuesday, January 15, 2013 - 20:50
in Health & Medicine
By using synthetic fibrils made from pure recombinant protein, researchers have provided the first direct and compelling evidence that tau fibrils alone are entirely sufficient to recruit and convert soluble tau within cells into pathological clumps in neurons, followed by transmission of tau pathology to other inter-connected brain regions from a single injection site in an animal model of tau brain disease.