MicroRNA makes triple-negative breast cancer homesick
Friday, November 23, 2012 - 15:30
in Health & Medicine
Carcinoma cells are epithelial cells gone bad and have learned to act like neurons, inappropriately activating TrkB signaling to escape the programmed cell death known as anoikis. They do it by a mutation that nixes production of a microRNA called miR-200c. When researchers reintroduced miR-200c to aggressive, triple-negative breast cancer cells, these cells regained sensitivity to anoikis and self-destructed.