Molecular mechanism contributing to cardiomyopathy elucidated

Sunday, April 1, 2012 - 15:30 in Biology & Nature

Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Forms of the disease were tied to the alternative splicing of titin, a giant protein that determines the heart`s structure and biomechanical properties, but the molecular mechanism remained unknown. Scientists have now found that a gene tied to hereditary cardiomyopathy, regulates titin splicing. Their findings could lead to improve diagnosis and therapies.

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