New approaches needed for treating chronic myeloid leukemia

The drug imatinib transformed chronic myeloid leukemia (CML) from a fatal disease to a chronic condition. However, imatinib must be taken lifelong, because it fails to kill a residual number of CML cells. New research, has now determined why these cells don't respond to imatinib -- they do not need the protein imatinib targets for their survival. Therefore, new approaches are needed if further advances are to be made in the care of CML patients.

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