Loss Of Tumor-suppressor And DNA-maintenance Proteins Causes Tissue Demise
Wednesday, October 21, 2009 - 20:07
in Health & Medicine
A new study demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy.