Just A Little Squeeze Lets Proteins Assess DNA

To find its target, all a protein needs to do is give quick squeezes as it moves along the DNA strand, suggests new research. Scientists had thought DNA-binding proteins primarily used full-body hugs for accurate readings of the information coded in the DNA's sequence. Doing the quick squeezes that scientists call indirect readout probably works faster, the researchers said. The finding has implications for the development of designer drugs.

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