Anti-VEGF Drugs For Retinal Diseases Could Have Serious Side Effects, Scientists Caution

Scientists have found that reducing the levels of vascular endothelial growth factor (VEGF), which is best known as a stimulator of new blood vessel growth, in adult mice causes the death of photoreceptors and Muller glia -- cells of the retina that are essential to visual function. This finding holds implications for the chronic use of promising new anti-VEGF drugs such as Lucentis, which eliminate abnormal and damaging blood vessel growth in the retina by neutralizing VEGF.

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