A protein with an unprecedented fold helps bacteria uptake thiosulfate as a sulfur source

A new study led by researchers at Nara Institute of Science and Technology (NAIST), Nara, Japan, published in Science Advances, reports the crystal structure of YeeE, a membrane protein that allows bacteria to uptake thiosulfate from the environment in order to synthesize L-cysteine. The structure reveals that YeeE has a characteristic hourglass shape that results in a sophisticated mechanism for the uptake, providing fundamental information that could greatly lower cysteine production costs in industry.

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