Researchers discover how enzyme protects cells from DNA damage
Monday, August 17, 2020 - 10:00
in Biology & Nature
A research team from Mount Sinai has unraveled for the first time the three-dimensional structure and mechanism of a complex enzyme that protects cells from constant DNA damage, opening the door to discovery of new therapeutics for the treatment of chemotherapy-resistant cancers. In a study published in Nature Structural & Molecular Biology in August, the researchers described how they used advanced cryo-electron microscopy to gain detailed insights into the enzyme known as DNA polymerase ζ (Pol ζ), whose architecture and mechanism have been a mystery to scientists for years.