OPTN-ATG9 interaction accelerates autophagic degradation of ubiquitin-labeled mitochondria
Thursday, July 9, 2020 - 10:20
in Biology & Nature
Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria to induce selective autophagy called mitophagy. Dysfunction of this type of mitophagy causes a decrease in mitochondrial quality and an overproduction of ROS, and thus is linked to the development of hereditary recessive Parkinson's disease.