Researchers discover a novel mechanism regulating planar cell polarity

Planar cell polarity (PCP), a process in which the epithelial tissues are polarized within the plane of the epithelium, plays an important role in development and organ function. Defects in PCP are associated with a variety of human diseases including cancer metastasis, neurological disorders, skeletal dysplasias and congenital heart disease. The establishment of PCP is regulated by an evolutionarily conserved set of signaling proteins. After their synthesis, many of these PCP proteins are delivered along the secretory transport pathway to the cell surface, where they perform their physiological functions. However, the molecular mechanisms that regulate PCP protein transport remain largely unclear.

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