Streamlined and scalable CHANGE-Seq method improves understanding of genome editors
Tuesday, June 16, 2020 - 08:20
in Biology & Nature
Scientists at St. Jude Children's Research Hospital have developed an easy to use, sensitive and high-throughput method to define sites of unintended double stranded breaks in DNA caused by genome editors like the CRISPR-Cas9 technique. They called the method Circularization for High-throughput Analysis of Nuclease Genome-wide Effects by Sequencing (CHANGE-seq). The work appears as an advance online publication today in Nature Biotechnology.