Stable and functional dyes for near-infrared fluorescence imaging of living subjects
Thursday, June 4, 2020 - 09:11
in Biology & Nature
Scientists can monitor biomolecular processes in live tissue by noninvasive optical methods, such as fluorescence imaging. However, the fluorescent dyes used for that purpose are often rather unstable, and photobleaching, lack of specificity, and poor pharmacokinetics are recurrent issues. US scientists have developed a molecular shield that stabilizes near-infrared fluorescent dyes and enhances their functionality. Their synthesis and characterization are reported in the journal Angewandte Chemie.