Enabling functional genomics studies in individual cells
Tuesday, June 2, 2020 - 09:20
in Biology & Nature
Although the first complete sequence of the human genome was reported more than 15 years ago, the biological functions of large parts of the genome are not yet known. Scientists working in the field of functional genomics try to understand these functions, and how our genome determines our individual traits and the course of diseases. High-throughput methods, such as CRISPR–Cas9 genome editing, allow scientists to study the functions of genomic elements in a systematic way. They use CRISPR–Cas9 to modify thousands of genes in a single experiment, but analyzing the biological effects of these modifications is challenging.