A genome-scale map of DNA methylation kinetics
Tuesday, June 2, 2020 - 08:50
in Biology & Nature
While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from the Schübeler group now quantified actual rates of methylation and demethylation for 860,404 individual CpGs in mouse embryonic stem cells. Their study reveals highly variable and context-specific activity for the DNA methylation machinery.