Proteasome phase separation for destruction
Monday, April 27, 2020 - 12:10
in Biology & Nature
The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and neurodegeneration. However, we do not yet know the overall principles behind UPS. In this study, the research team discovered a novel mode of protein degradation by the UPS under a stress condition.