The Lipid Code: New chemical tools can control the concentration of lipids in living cells
Lipids, or fats, have many functions in our body: They form membrane barriers, store energy or act as messengers, which regulate cell growth and hormone release. Many of them are also biomarkers for severe diseases. So far, it has been very difficult to analyze the functions of these molecules in living cells. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden and the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin have now developed chemical tools that can be activated by light and used to influence lipid concentration in living cells. This approach could enable medical doctors to work with biochemists to identify what molecules within a cell actually do. The study was published in the journal PNAS.