Engineering the P450 enzyme to perform new reactions

Enzymes, the micro machines in our cells, can evolve to perform new tasks when confronted with novel situations. But what if you want an enzyme to do an entirely different job—one that it would never have to do in a cell? In a recent report published in ACS Central Science, researchers show that they can mimic nature and perform evolution in a test tube, developing enzymes that can perform brand-new chemical reactions.

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