Earliest stages of ear development involve a localized signaling cascade

The proteins associated with driving the cell shape changes that internalize the embryonic inner ear have been identified by Raj Ladher and colleagues from the RIKEN Center for Developmental Biology. "Our hope," says Ladher, "is that by understanding the morphogenesis of the inner ear, clinicians will become more aware of what to look for in their diagnosis of otic developmental defects."

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