Illuminating the dark side of the genome
Tuesday, July 29, 2014 - 03:00
in Biology & Nature
Almost 50 percent of our genome is made up of highly repetitive DNA, which makes it very difficult to be analysed. In fact, repeats are discarded in most genome-wide studies and thus, insights into this part of the genome remained limited. Scientists from the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg now succeeded in examining this dark side of the genome. Their analyses revealed that repeat-associated heterochromatin is essential to repress retrotransposons and thereby protects the genomic integrity of stem cells. This work opens the way for future genome-wide analyses of repetitive regions in the genome and is in line with newly emerging functions for heterochromatin.