Enhanced NIST instrument enables high-speed chemical imaging of tissues

Tuesday, July 22, 2014 - 13:00 in Physics & Chemistry

A research team from the National Institute of Standards and Technology (NIST), working with the Cleveland Clinic, has demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures." The new NIST technique is an advanced form of the widely used spontaneous Raman spectroscopy, but one that delivers signals that are 10,000 times stronger than obtained from spontaneous Raman scattering, and 100 times stronger than obtained from comparable "coherent Raman" instruments, and uses a much larger portion of the vibrational spectrum of interest to cell biologists.

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