Lost in translation: Gene expression changes don't always alter protein levels
Monday, October 28, 2013 - 07:30
in Biology & Nature
(Phys.org) —The central dogma of biology is that DNA gives rise to mRNA, which then gives rise to protein. Thus, it has been widely assumed that changes in specific mRNA levels are always accompanied by commensurate changes in the encoded proteins and vice versa. To determine whether this is always the case, scientists at Pacific Northwest National Laboratory examined Shewanella oneidensis MR-1 grown under steady state conditions at either 20% or 8.5% O2.