Novel molecules to fight cancer resistance
A French-Italian team headed by researchers from CNRS and Inserm has discovered a new family of compounds that could make it possible to treat numerous cancers, particularly brain tumors and skin cancers. These substances, patented by CNRS, block a chain of molecular reactions known as the Hedgehog signaling pathway, the disruption of which could be involved in several cancers. These compounds could become new medicines in the long term. In the short term, they should prove to be precious tools in elucidating the role of the Hedgehog pathway in the development of these tumors and their resistance to treatment. This work, carried out in collaboration with the Laboratoire d'Innovations Thérapeutiques, is published in the Journal of Medicinal Chemistry.