Breakdown of triglycerides in heart muscle boosts cardiac function
Wednesday, February 15, 2012 - 15:00
in Health & Medicine
The heart relies heavily on oxidation of fatty acids for energy production. However, excess storage of fatty acids as triglycerides, within heart muscle cells, frequently observed in patients with obesity and diabetes, is often associated with cardiac dysfunction. The question remained: was this cause and effect? Now a team of investigators shows that baseline heart function "showed moderate, but significant improvement" in mouse models that overproduce an enzyme that breaks down these triglycerides, says principal investigator Jason Dyck, of the University of Alberta, Edmonton. The research is published in the February Molecular and Cellular Biology.