Signaling to chromatin
Tuesday, January 3, 2012 - 08:31
in Biology & Nature
(Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research (FMI) in collaboration with their colleagues from the Department of Biosystems Science and Engineering of the ETH Zurich, describe how the signaling molecule JNK directly modifies histones to alter gene transcription. As JNK acts in a signaling pathway that is impaired in every third form of cancer, the results published in Nature Genetics open up a new pathway for kinase regulated gene expression and potential therapeutic intervention.