Researchers discover key molecule for stem cell pluripotency

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. This pluripotency depends on a specific molecule – E-cadherin – hitherto primarily known for its role in mediating cell-cell adhesion as a kind of "intracellular glue". If E-cadherin is absent, the stem cells lose their pluripotency. The molecule also plays a crucial role in the reprogramming of somatic cells (body cells) into pluripotent stem cells.

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