Key regulator of nervous system development works by blocking signaling protein

Neuroepithelial stem cells, the early progenitors for much of the nervous system, need to maintain a keen sense of direction in order to properly manage replication, migration and maturation. These cells are highly polarized, and exclusively initiate cell division at their apical (top) end rather than at their basal (bottom) end, although it has remained a mystery how they determine which way is up.

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