Parasite-induced genetically driven autoimmune chagas disease

Tuesday, March 29, 2011 - 17:01 in Biology & Nature

Researchers have shown that the Trypanosoma cruzi agent of Chagas Disease (CD) invades host embryo cells and spreads its mitochondrial DNA (kDNA) minicircles into the host's genome. Dr. Antonio Teixeira and associates at the University of Brasília, Brazil, inoculated virulent typanosomes in fertile chicken eggs and documented the heritability and fixation of the kDNA mutations in the chicks and their progeny. The results, published in the open-access journal PLoS Neglected Tropical Diseases on March 29th, show that kDNA-mutated chickens undergo genotype alterations, developing an inflammatory heart condition similar to Chagas disease in humans.

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