When leukemia returns, gene that mediates response to key drug often mutated
Wednesday, March 9, 2011 - 14:30
in Health & Medicine
Despite dramatically improved survival rates for childhood acute lymphoblastic leukemia (ALL), relapse remains a leading cause of death from the disease. Work led by St. Jude Children's Research Hospital investigators identified mutations in a gene named CREBBP that may help the cancer resist steroid treatment and fuel ALL's return.