IL28B gene predicts treatment outcome for liver transplantation patients

Wednesday, March 2, 2011 - 13:31 in Health & Medicine

German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a marker for severe HCV-induced graft inflammation, as well as a predictor for unsuccessful treatment. Study findings -- the largest to report on the role IL28B variants in a transplant cohort with recurrent HCV -- are published in the March issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases.

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