Tolerating foreign materials in food

An international team of molecular biologists led by RIKEN researchers (Japan) has unraveled key details of the molecular mechanism whereby the body’s immune system determines what to attack among the organisms and food taken into the mouth, and what to leave alone or tolerate. The researchers have shown the pivotal role of two proteins found on the surface of cells that stimulate the immune system into action, the dendritic antigen-presenting cells (APCs). The work may lead to new therapies for immune disorders, and to ways of boosting the effectiveness of oral vaccines.

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