AFM positioning: Shining light on a needle in a haystack

The researchers characterize their new technique as a neat solution to the "needle in a haystack" problem of nanoscale microscopy, but it's more like the difference between finding the coffee table in a darkened room either by walking around until you fall over it, or using a flashlight. In a new paper,* a group from JILA—a joint venture of the National Institute of Standards and Technology and the University of Colorado -- finds tiny assemblies of biomolecules for subsequent detailed imaging by combining precision laser optics with atomic force microscopy.

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