A new role of glypican-3 in hepatocellular carcinoma

A study group from Japan analyzed the association of glypican-3 (GPC3) expression with Wnt and other growth signaling molecules in hepatocellular carcinoma (HCC). They found altered expressions of various matrix metalloproteinases (MMPs) and growth signaling molecules, some of which were correlated with GPC3 expression, were observed in HCCs. The results suggest that GPC3, in conjunction with MMPs and growth signaling molecules, might play an important role in the progression of HCC.

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