New requirements for male fertility

Two independent groups of researchers have identified distinct roles for two proteins in a family of proteins known as PLA2s as crucial for sperm function and fertility in mice. These data identify proteins that could underlie causes of infertility and provide potential targets for the development of new contraceptive agents and new approaches to treating infertility. In addition, these data provide a caution to those developing drugs that target members of this closely related group of proteins to treat hardening of the arteries (atherosclerosis) and inflammation.

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