Different signaling pathways of cholangiocarcinoma

Overexpression of receptor tyrosine kinase Met has frequently been found in cholangiocarcinoma. A research group in Thailand demonstrated that hepatocyte growth factor, a Met ligand, induced invasion and motility and altered E-cadherin localization in two cholangiocarcinoma cell lines, without having any significant effects on levels of two secreted matrix metalloproteinases. However, the signaling pathways underlying HGF-induced invasiveness of the two cell lines were different.

Read the whole article on Physorg

More from Physorg