Which intestinal metapasia is closer with gastric cancer? Simple or atypical?

The classification of intestinal metapasia (IM) is confusing. A research group in China observed IM in gastric biopsies and divided IM into simple IM (SIM) and atypical IM (AIM). By detecting three tumor-associated proteins, p53, c-erbB-2 and Ki67, in IM and gastric cancer, they compared two types of classification in intestinal metaplasia. They found that AIM may have a much more close relationship with gastric cancer.

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