Deciphering the regulatory code: Scientists take new approach to predict gene expression

Embryonic development is like a well-organised building project, with the embryo's DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes. These patterns of gene expression are controlled by transcription factors: molecules which bind to stretches of DNA called cis-regulatory modules (CRMs), and, once bound, switch the relevant genes on or off.

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