Examining genetic variations among the Huichol population of Mexico

Mexican researchers examined the polymorphisms of three enzymes -- alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2) and cytochrome P4502E1 (CYP2E1) -- in the Mestizo and Huichol groups.The Huichols, an indigenous group, had the highest CYP2E1*c2 allele frequency documented in the world.This high frequency, in conjunction with the absence of protective ADH1B and ALDH2 polymorphisms, may place the Huichols at particularly high genetic risk for alcoholism and alcoholic liver disease.

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